New Strength of Bio-manufacturing: Ten New Products of Synthetic Biology Released by Shenzhen in 2023

The medical adhesives with both hemostatic and adhesive properties and AI-based and super-large scale automated laboratory cluster solution...On April 27-28, the Engineering Biology Innovation Forum IV · Guangming Science City 2023, the SynBio China II and the Asian Synthetic Biology Innovation Forum I (hereinafter referred to as the event) were held. At the conference, the Synthetic Biology Institute of SIAT, Shenzhen Institute of Synthetic Biology and SIAT University (preparatory) jointly released the top ten new synthetic biology products of Shenzhen in 2023.

As the third biotechnology revolution after the “double helix structure of DNA” and “genome technology”, synthetic biology has deeply integrated multiple cutting-edge sciences such as molecular and cellular biology, engineering, biochemistry, and information technology, which is widely used in such fields as health, chemical industry and energy, food and beverage, information storage, and biological devices to provide new solutions for major issued and problems faced by the humankind such as health and medical treatment, energy and environment. In recent years, thanks to technological breakthroughs, policy support and other factors, China’s bio-manufacturing has been thriving, and the biological economy has witnessed an explosive growth. It’s predicted by McKinsey data that by 2025, the economic value of synthetic biology and bio-manufacturing will reach $100 billion, and 60% of the world’s material production can be achieved through bio-manufacturing in the future.

As a new force in bio-manufacturing, the top 10 new products of 2023 covered application tracks such as chemicals, medical care, organism construction and automation platform, and food, which will bring new technology changes and industrial upgrades to different application fields of bio-manufacturing.

On the race track of chemicals, the recombinant mussel protein released by PAML Biotechnology can be used to develop medical adhesives and recombinant mussel mucin repair dressings with both hemostatic and adhesive properties, which can be used to heal surgical incision at body surface, prevent scar formation and chromatosis, repair of skin barrier damage caused by dermatitis. The SOD in the SYSTASE® SOD product released by Siyomicro is an enzyme widely found in living organisms, which plays an important role in maintaining the metabolic balance of the body, and can be used in such fields as food, skin care products, medical care and medicine. The new lysozyme - Sa antibacterial protein product released by Biocre Tech is made from the raw material of new lysozyme protein, which can target and inhibit the Staphylococcus aureus. As a skin care efficacy ingredient added to skin care products with related efficacy such as removal of acne, soothing, and repair, it has certain improving effects for skin problems such as eczema in children and atopic dermatitis. The natural pigment dye of bio-synthetic indigo released by Daosheng Biological Technology shows characteristics such as mild production conditions, a short cycle, a high efficiency and good quality, which is used in such fields as food, medicine, cosmetics and printing and dyeing industry. 

On the race track of medical care, RH315, a new free-dried herpes zoster mRNA vaccine developed by Rhegen based on its mRNA technology platform with an independent intellectual property - R4 platform. Its pre-clinical efficacy and safety evaluation indicators are significantly better than those of other rival products. The freeze-dried preparation can be stored and transported in 2-8℃. On the whole, it is safe and effective and controllable in industrialization and has reached the world’s leading level. The multifunctional cell processing system released by Saiqiao Biotechnology can realize the closure, automation, flexibility, digitalization and intelligence of industrial core equipment in the field of cell and gene therapy, which is used for efficient cell separation, activation, engineering reorganization, high expansion, purification and high precision liquid route control in the whole process. The recombinant living biological drugs released by Xbiome can relieve inflammation, improve cell proliferation and vascular regeneration, which is used to treat diabetic foot ulcers and heal chronic wounds.

On the race track of biological construction and automation platform, the AI-based and super-large scale automated laboratory cluster solution released by XtalPI. Using intelligent synthesis workstation and automated experimental robot, it achieves high-throughput experimental verification. The non-grain carbon source bio-refining platform released by Xunyuan Technology provides one-stop production line service of “planting, harvest, storage, transportation, construction and use” for biomass conversion technology. On the race track of food, low-purine sparkling wine released by Biosysen was developed relying on its own culture collection, automated strain breeding platform, high-throughput fermentation system and omics platform, with characteristics such as low miscellaneous alcohol, low purine, no sugar, no gluten and a pure and fresh taste. 

Core technology is vital to the nation. Realizing a high level of self-reliance and strength in science and technology is the only way to promote high-quality development. The National Development and Reform Commission proposed in the Fourteenth Five-Year Plan for Bioeconomic Development that the proportion of bioeconomy added value in the GDP during the Fourteenth Five-Year Plan period should increase steadily, and the bioeconomy should become a strong driving force for high-quality development. The Opinions of Shenzhen Municipal People’s Government on the Development and Growth of Strategic Emerging Industrial Clusters and Cultivation and Development of Future Industries listed the biomedical industry cluster among the strategic emerging industries and listed synthetic biology among the key directions of industrial development, and supported the construction of synthetic biology infrastructure and synthetic biology R&D bases and industrial innovation centers. Under the support of China’s policy and regional industrial layout, Shenzhen has become a highland of synthetic biology industry in China. According to incomplete statistics, the newly established synthetic biology enterprises in Shenzhen since 2020 have accounted for about 40% of the total in China. Relying on a series of carriers such as “Shenzhen Synthetic Biology Infrastructure”, “Shenzhen Institute of Synthetic Biology”, “the School of Synthetic Biology of SIAT University (preparatory)” and “Shenzhen Industrial Innovation Center for Synthetic Biology”, Shenzhen has deeply integrated the innovation chain, industrial chain, capital chain and talent chain of synthetic biology to build a new ecology for the innovation of bio-manufacturing and build a new engine for bioeconomy.