异源核酸（XNA）替代天然核酸做为遗传物质的可能性探讨，及以其为基础的核酸药物和诊断试剂开发；新颖化学工具和方法的开发以及其在药物化学、化学生物学和合成生物学中的应用等。
梅辉，中国科学院深圳先进技术研究院副研究员。北京大学药学学士，北京大学化学生物学硕士，德国奥斯纳布吕克大学博士，美国斯坦福大学化学系博士后。研究成果以第一作者发表在J. Am. Chem. Soc., Nucleic Acids Res., ChemComm, Biomacromolecules等国际专业学术期刊。
联系方式:0755-86575289
E-mail: hui.mei@siat.ac.cn
个人网站：http://isynbio.siat.ac.cn/meilab/
论文发表节选
H. Mei, R. Liao, J. Randi, Y. Wang, S. Bala, C. McCloskey, C. Switzer, J. C. Chaput*, Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7- Deaza-7-Substituted Guanosine Residues, J. Am. Chem. Soc., 2018, 140: 5706-5713.
H. Mei, J. C. Chaput*, Expanding the Chemical Diversity of TNA with tUTP Derivatives that are Substrates for a TNA Polymerase, Chem. Commun., 2018, 54: 1237-1240.
H. Mei, C. Shi, J. Randi, Y. Wang, M. Kardouh, J. C. Chaput*, Synthesis and Polymerase Activity of a Fluorescent Cytidine TNA Triphosphate Analogue, Nucleic Acids Res., 2017, 45: 5629-5638.
H. Mei, S. A. Ingale, F. Seela*, Imidazolo-dC Metal-Mediated Base Pairs: Purine Nucleosides Capture Two Ag+ Ions and Form a Duplex with the Stability of a Covalent DNA Cross-Link, Chem. Eur. J., 2014, 20: 16248-16257.
H. Mei, S. Budow, F. Seela*, Construction and Assembly of Chimeric DNA: Oligonucleotide Hybrid Molecules Composed of Parallel or Antiparallel Duplexes and Tetrameric i-Motifs. Biomacromolecules, 2012, 13: 4196-4204.