Nan Li is a Professor and PI of the Chemical Proteomics team in Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences.
Nan Li obtained his bachelor's degree in chemical biology from Xiamen University and a master's and doctorate in biochemistry and molecular biology from the University of Leiden, the Netherlands. He developed a chemical proteomics approach as a comprehensive way of quantifying the activity of different subunits of the proteasome in complex biological systems and is published in Nature Protocols. The method is widely used by more than ten laboratories all over the world for the screening of novel proteasome inhibitor drugs and is collected as a chapter in the textbook Concept and Case Studies in Chemical Biology. Nowadays, his team is focusing on the development and application of new methodology using innovative chemical proteomics technology, to address questions from fundamental biological research and biotech industry.
TEL：0755-86704727
EMAIL：nan.li@siat.ac.cn
WEBSITE：http://isynbio.siat.ac.cn/chemoproteomics/
Publications/Patents (selected)
Joel Selkrig, Nan Li, Annika Hausmann , Matthew S. J. Mangan, Matylda Zietek, Andre Mateus , Jacob Bobonis , Anna Sueki, Haruna Imamura, Bachir El Debs, Gianluca Sigismondo, Bogdan. Florea, Herman S. Overkleeft, Natasa Kopitar Jerala , Boris Turk, Pedro Beltrao, Mikhail M. Savitski , Eicke Latz, Wolf Dietrich Hardt, Jeroen Krijgsveld and Athanasios Typas .(2020). Spatiotemporal proteomics uncovers cathepsin dependent macrophage cell death during Salmonella infection.Nat.Microbiology
Bao X, Guo X, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B, Esteban MA.(2018).Capturing the interactome of newly transcribed RNA.Nat Methods.
Soriano GP, Besse L, Li N, Kraus M, Besse A, Meeuwenoord N, Bader J, Everts B, den Dulk H, Overkleeft HS, Florea BI, Driessen C. （2016）.Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes in particular in redox and energy metabolism. Leukemia.
Li N, Kuo CL, Paniagua G, van den Elst H, Verdoes M, Willems LI, van der Linden WA, Ruben M, van Genderen E, Gubbens J, van Wezel GP, Overkleeft HS and Florea BI.（2013）.Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS.Nat Protoc.
Willems LI, Li N, Florea BI, Ruben M, van der Marel GA, Overkleeft HS.（2012）.Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities.Angew Chem Int Ed Engl.