HUEN, Michael Shing YanVisiting Professor

DNA Damage Detection and Repair Control

Dr. Michael Huen is Professor of the School of Biomedical Sciences and Assistant Dean (Innovation and Technology) of the LKS Faculty of Medicine at The University of Hong Kong. He majored in biochemistry at the Hong Kong University of Science and Technology, and received his doctorate degree at the University of Hong Kong in 2006 studying bacteriophage-mediated DNA recombination. He later trained with Prof. Junjie Chen at Mayo Clinic / Yale University where he developed an interest for DNA damage detection and repair control in mammalian cells. His major research goal aims to define the functional connectivity of the DNA Damage Response protein network, and to rationalize how perturbed DNA damage responses contribute to genome instability and associated diseases, including cancer.


Publications/Patents (recent)

An L, Dong C, Li J, Chen J, Yuan J, Huang J, Chan KM, Yu CH, Huen MS. RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair. PNAS 2018; 115(35): E8286-8295.

Chen Y, Li J, Cao F, Lam J, Cheng CC, Yu CH, Huen MS. Nucleolar residence of the Seckel Syndrome protein TRAIP is coupled to ribosomal DNA transcription. Nucleic Acids Res 2018; 46(19): 10119-10131.

An L, Jiang Y, Ng HH, Man EP, Chen J, Khoo US, Gong Q, Huen MS. Dual-utility NLS drives RNF169-dependent DNA damage responses. PNAS 2017; 114(4): E2872-2881.

Guo Y, An L, Ng HM, Sy SM, Huen MS. An E2-guided E3 screen identifies the RNF17-UBE2U pair as regulator of the RIDDLE syndrome protein RNF168. J Biol Chem 2017; 292(3):967-978.

Feng W, Guo Y, Huang J, Deng Y, Zang J, Huen MS. TRAIP regulates replication fork recovery and progression via PCNA. Cell Discovery 2016; 2:16016.