Dr. Xuemei Lu, Professor, Principle Investigator. Adaptive evolution can happen at various levels, population, organism, or cellular. Both organ exhaustion and cell abnormal proliferation are involved in accumulation of somatic mutation and adaptation evolution. An obvious manifestation of such short-term evolution is cancer. The evolution theory is applicable at organism and cell population levels. Carrying out the approaches in population genetics, evolutionary biology and genomics, we study the genetic and epigenetic basis of species adaptation, and the dynamic accumulation process and features of somatic as well. Based on this framework, we are depicting the pattern of mutation accumulation and selection, as well as identifying crucial mutations driving fitness changes in animal organisms and tumor cells.
E-mail: xuemeilu@mail.kiz.ac.cn
Website: http://sourcedb.kiz.cas.cn/zw/zjrc/gjzd/201907/t20190719_5344526.html
Publications/Patents (recent)
Zhang, Y., Y. Li, T. Li, X. Shen, T. Zhu, Y. Tao, X. Li, D. Wang, Q. Ma, Z. Hu, J. Liu, J. Ruan, J. Cai, H.Y. Wang and X. Lu, Genetic Load and Potential Mutational Meltdown in Cancer Cell Populations. Mol Biol Evol, 2019. 36(3): p. 541-552.
Xiang, Y., K. Yan, Q. Zheng, H. Ke, J. Cheng, W. Xiong, X. Shi, L. Wei, M. Zhao, F. Yang, P. Wang, X. Lu, L. Fu, X. Lu and F. Li, Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1. Cancer Research, 2019. 79(1): p. 86.
Liu, S., Z. Yang, G. Li, Y. Luo, Q. Gong, X. Wu, T. Li, Z. Zhang, B. Xing, X. Xu and X. Lu, Abstract 208: Multi-omics analysis in primary cell cultures reveals the genomic basis of phenotypic diversity within tumors. CANCER RESEARCH, 2018. 78: p. 208-208.
Ye, W., S. Ling, R.Y. Liu, Z.Z. Pan, G. Wang, S. Gao, J. Wu, L. Cao, L. Dong, Y. Li, Y. Zhou, W. Du, X. Meng, J. Chen, X. Guan, Y. He, C. Pan, X.F. Steven Zheng, X. Lu, S. Chen and W. Huang, Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers. J Pathol, 2018.
Li, C., Y. Hou, J. Xu, A. Zhang, Z. Liu, F. Qi, Z. Yang, K. Chen, S. Liu, H. Huang, Q. Wang, J. Dong, C.I. Wu and X. Lu, A Direct Test of Selection in Cell Populations Using the Diversity in Gene Expression within Tumors. Mol Biol Evol, 2017. 34(7): p. 1730-1742.