Xinyuan GUANVisiting Professor

Focused on finding genes, cancer stem cells and tumor microenvironment associated with HCC, esophageal cancer and nasopharyngeal carcinoma.

Prof. Xin-Yuan Guan got his PhD degree in 1993 at the University of Arizona. He was recruited by the National Human Genome Research Institute in NIH as a senior staff fellow. In 1999, Prof. Guan joined the Department of Clinical Oncology, The University of Hong Kong as an Associated Professor. He was promoted as Professor in 2007 and Chair Professor in 2018. He is now the Sophie YM Chan Professor in Cancer Research, Deputy Director of State Key Laboratory for Liver Research, and Director of Laboratory of Cancer Genetics, Li Ka Shing Faculty of Medicine, the University of Hong Kong. Prof. Guan's research interests include the identification and characterization of cancer-related genes, cancer stem cells and cancer microenvironment in hepatocellular, esophageal and nasopharyngeal carcinomas. Prof. Guan has published more than 320 peer-reviewed papers in international journals including in Nature Genetics, Cell Stem Cell, Nature Medicine, which have been cited for more than 23,800 times. He got many awards including National Outstanding Young Research Award (Type B, 1998), Outstanding Research Award of The University of Hong Kong (2012), Outstanding Research Student Supervisor Award of The University of Hong Kong (2016). State Natural Sciences Award of China (Second-class, 2010) and State Scientific and Technological Progress Award of China (First-class, 2012).



Publication/Patents (recent)

Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY*. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology 2016;63:1544-59.

Song Y, Pan G, Chen L, Ma S, Zeng T, Chan TH, Li L, Lian Q, Chow R, Cai X, Li Y, Li Y, Liu M, Li Y, Zhu Y, Wong N, Yuan YF, Pei D, Guan XY*. Down-regulation of tumor suppressor ATOH8 increases cancer stemness in hepatocellular carcinoma. Gastroenterology 2015;149:1068-81.

Li Y*, Fu L, Qin Y, Zeng T, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma. Gastroenterology 2014;146:1701-13.

Liu M, Li Y, Chen L, Chan TH, Song Y, Fu L, Zeng TT, Dai YD, Zhu YH, Li Y, Chen J, Yuan YF, Guan XY*. Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma. Gastroenterology 2014;146:1084-96.

Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG*, Guan XY*. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nature Medicine 2013;19(2):209-16.