Genomics, Bioinformatics, Computational Biology, Sequencing technologies, Cancer Diagnostics, Microfluids based Diagnostics
A multi-disciplined technologist with experience in pharmaceutical, biotech, diagnostic and software industries. I am particularly interested in developing big data application and genomics based diagnostic products.
Mail：heng.dai@sinotechgenomics.com
Publications/Patents (recent)
Assessment of tumor mutation burden calculation from gene panel sequencing data. Xu Z, Dai J, Wang D, Lu H, Dai H, Ye H, Gu J, Chen S, Huang B. OncoTargets and Therapy, Volume 12, 3401–3409. doi:10.2147/ott.s196638
BreakID: genomics breakpoints identification to detect gene fusion events using discordant pairs and split reads. Jin L, Lai J, Zhang Y, Fu Y, Wang SH, Dai H, Huang B. Bioinformatics, 2019 Jan, https://doi.org/10.1093/bioinformatics/bty1070
Whole-genome mutational burden analysis of three pluripotency induction methods. Bhutani K, Nazor KL, Williams R, Tran H, Dai H, Džakula Ž, Cho EH, Pang AW, Rao M, Cao H, Schork NJ, Loring JF. Nature Communication. 2016 Feb 19;7:10536. doi: 10.1038/ncomms10536.
Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays. Mak AC, Lai YY, Lam ET, Kwok TP, Leung AK, Poon A, Mostovoy Y, Hastie AR, Stedman W, Anantharaman T, Andrews W, Zhou X, Pang AW, Dai H, Chu C, Lin C, Wu JJ, Li CM, Li JW, Yim AK, Chan S, Sibert J, Džakula Ž, Cao H, Yiu SM, Chan TF, Yip KY, Xiao M, Kwok PY. Genetics. 2016 Jan;202(1):351-62. doi: 10.1534/genetics.115.183483. Epub 2015 Oct 28.
Assembly and Diploid Architecture of an Individual Human Genome via Single Molecule Technologies., Pendleton M, Sebra R, Pang AW, Ummat A, Franzen O, Rausch T, Stütz AM, Stedman W, Anantharaman T, Hastie A, Dai H, Fritz MH, Cao H, Cohain A, Deikus G, Durrett RE, Blanchard SC, Altman R, Chin CS, Guo Y, Paxinos EE, Korbel JO, Darnell RB, McCombie WR, Kwok PY, Mason CE, Schadt EE, Bashir A., Nature Methods. 2015 Aug;12(8):780-6. doi: 10.1038/nmeth.3454. Epub 2015 Jun 29.
CN110195095A. A method to construct methylation based genomic library and its application. Shanghai Jingzhou Genomics Zhang Y, Dai H. et al.
CN108830044A. A method for detecting gene fusion in cancer samples. Shanghai Jingzhou Genomics. Huang BD, Dai H. et.al.
CN106834502B. A method of capture and NGS-based diagnostic kit to detect SMN1/2 Copy Number Variation. WuXi NextCODE Genomics, Xin M, Peng JL, Dai H.