Zheng Hu, PhD and Professor, obtained B.S. in Biomedical Engineering from Huazhong University of Science and Technology in 2010 and obtained Ph.D. in Genetics from Beijing Institute of Genomics, Chinese Academy of Sciences in 2015. Dr. Hu completed
postdoctoral training at Stanford University School of Medicine during 2015-2020. Dr. Hu’s research is focusing on understanding the processes and mechanisms of somatic evolution in normal tissue and cancer development by integrating approaches in genomics, computational biology and evolutionary biology. Dr. Hu’s group aims to exploit principles in clonal evolution to guide prevention and treatment of cancers.
EMAIL: zheng.hu@siat.ac.cn
WEBSITE: https://www.zhenghulab.org/
Publications/Patents (selected)
Hu Z, Li Z, Ma Z, javascript:editControl('txtDetail');Curtis C. (2020) Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases. Nature Genetics. 52; 701–708.
Hu Z*, Curtis C*. (2020) Looking backward in time to define the chronology of metastasis. Nature Communications. 11, 3213. (*corresponding author)
Hu Z, Ding J, Ma Z, Sun R, Suarez CJ, Seoane JA, Shaffer JS, Berghoff AS, Antoniotti C, Falcone A, Loupakis F, Birner P, Lenz HJ, Preusser M, Curtis C. (2019) Quantitative evidence for early metastatic seeding in colorectal cancer. Nature Genetics. 51(7):1113-1122. (selected as cover article)
Sun R#, Hu Z#, Sottoriva A, Graham T, Harpak A, Ma Z, Fischer JM, Shibata D, Curtis C. (2017) Between-region genetic divergence reflects the mode and tempo of tumor evolution. Nature Genetics. 49(7):1015-1024. (#co-first author)
Ling S#, Hu Z#, Yang Z#, Yang F#, Li Y, Chen K, Dong L, Cao L, Tao Y, Hao L, Gong Q, Tian X, Hao C, Hudson RR, Hungate E, Lu X, Wu CI. (2015) Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution. Proc. Natl. Acad. Sci. U.S.A. 112(47): E6496-E6505. (#co-first author)