Zhengfan JIANGVisiting Professor


Professor Zhengfan Jiang is an expert in innate immunity against microbial infection and tumorigenesis. His lab discovered STING, the master regulator of virus infections and revealed the coordination among infection-induced cytokine production, inflammation and cell death. Their findings of Mn as an immune activator provided novel functions of Mn and the molecular basis for Mn-related adjuvants and immunotherapies. They also identified sulfated glycosaminoglycans in Golgi as coligands for STING and untranslocated/unactivated STING underwent phase separation to form “the STING Phase-separator” to prevent its overactivation. These works will be important for new drug designs in infection control and tumor therapies.

EMAIL: jiangzf@pku.edu.cn

Publications/Patents (recent)

Fang R, Jiang Q, Guan Y, Gao P, Zhang R, Zhao Z, and Jiang Z*. 2021, Golgi-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING.  Immunity In press. https://doi.org/10.1016/j.immuni. 2021.03.011

Yu X, Zhang L, Shen J, Zhai Y, Jiang Q, Yi M, Deng X, Ruan Z, Fang R, Chen Z, Ning X, Jiang Z*. 2021, The STING Phase-separator Suppresses Innate Immune Signaling.  Nature Cell Biology 23: 330-340.

Zhang R, Wang C, Guan Y, Wei X, Sha M, Jing M, Lv M, Guo W, Xu J, Wan Y, Jia X, Jiang Z*. 2021, Manganese salts function as potent adjuvants.  Cellular & Molecular Immunology. In press. https://doi.org/10.1038/s41423-021-00669-w

Lv M. Chen M, Zhang R, Zhang W, Wang C, Zhang Y, Wei X, Guan Y, Liu J, Feng K, Jing M, Wang X, Liu Y, Mei Q*, Han W*, Jiang Z*. 2020, Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy.  Cell Research 30: 966–979.

Zhao Z. Ma Z., Wang B, Guan Y, Su X*, Jiang Z*. 2020, Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces A Noncanonical Catalytic Synthesis of 2’3’-cGAMP.  Cell Reports 32(7): 108053.