Longlong Si is a professor in Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences.
Dr. Si received his B.Sc. degree from West China School of Pharmacy, Sichuan University, and Ph.D. in Chemical Biology from State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University. He was a Wyss Technology Development Fellow and Postdoc Fellow in Biomedical Engineering and Synthetic Biology at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School before he moved to SIAT as a professor. His works were published in Science, Nature Biomedical Engineering, Science Advances, Biomaterials, and other influential journals.
Major research directions: Biomedical Engineering, Human Organ-on-a-Chip, Virus Engineering.
Email: ll.si@siat.ac.cn
Website: http://isynbio.siat.ac.cn/SLlab/
Publications/Patents (recent)
Si L#, Bai H#, Rodas M, Cao W, Oh CY, Jiang A, Moller R, Hoagland D, Oishi K, Horiuchi S, Uhl S, Blanco-Melo D, Albrecht RA, Liu WC, Jordan T, Nilsson-Payant BE, Golynker I, Frere J, Logue J, Haupt R, McGrath M, Weston S, Zhang T, Plebani R, Soong M, Nurani A, Kim SM, Zhu DY, Benam KH, Goyal G, Gilpin SE, Prantil-Baun R, Gygi SP, Powers RK, Carlson KE, Frieman M, tenOever BR, Ingber DE*. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nature Biomedical Engineering 2021. https://doi.org/10.1038/s41551-021-00718-9 (#co-first author, *corresponding author)
Si L#, Bai H#, Oh CY, Jin L, Prantial-Baun R, Ingber DE*. Clinically relevant influenza virus evolution reconstituted in a human lung airway-on-a-chip. Microbiology Spectrum 2021. (#co-first author, *corresponding author)
Si L, Meng K, Tian Z, Sun J, Li H, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Zhou D*. Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes. Science Advances 2018; 4: eaau8408.
Si L#, Xu H#, Zhou X, Zhang Z, Tian Z, Wang Y, Wu Y, Zhang B, Niu Z, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science 2016; 354: 1170-1173. (#co-first author, *corresponding author)
Xiao S#*, Si L#, Tian Z, Jiao P, Fan Z, Meng K, Zhou X, Wang H, Xu R, Han X, Fu G, Zhang Y, Zhang L, Zhou D*. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect. Biomaterials 2016; 78: 74-85. (#co-first author, *corresponding author)