Yi-Ming Shi obtained his Ph.D. in Medicinal Chemistry from the Kunming Institute of Botany, Chinese Academy of Sciences. With the support of the Humboldt Foundation, he conducted postdoctoral research at Goethe University Frankfurt in Germany. He was later appointed as the Project Group Leader at the Max Planck Institute for Terrestrial Microbiology. Since 2023, he has become a professor at the Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences.
Email: ym.shi@siat.ac.cn
Link: https://sym-lab.net/
Selected publications：
[1] Shi, Y.-M.*; Hirschmann, M.; Shi, Y.-N.; Ahmed, S; Abebew, D.; Tobias, N. J.; Grün, P.; Crames, J. J.; Pöschel, L.; Kuttenlochner, W.; Richter, C.; Herrmann, J.; Müller, R; Thanwisai, A; Pidot, S. J.; Stinear, T. P.; Groll, M; Kim, Y.; Bode, H. B.* Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria. Nat. Chem. 2022, 14, 701-712
[2] Shi, Y.-M.*#; Crames, J. J.#; Czech, L.; Bozhüyük, K. A. J.; Shi, Y.-N.; Hirschmann, M.; Lamberth, S.; Paczia, N.; Rückert, C.; Kalinowski, J.; Bange, G.; Bode, H. B.* Genome mining enabled by biosynthetic characterization uncovers a widespread class of benzoxazolinate-containing natural products. Angew. Chem. Int. Ed. 2022, 61, e202206106.
[3] Shi, Y.-M.*; Hirschmann, M.; Shi, Y.-N.; Bode, H. B.* Cleavage off-loading and post-assembly-line conversions yield products with unusual termini during biosynthesis. ACS Chem. Biol. 2022, 17, 2221-2228
[4] Shi, Y.-M.; Brachmann, A. O; Westphalen, M. A.; Neubacher, N.; Tobias, N. J.; Bode, H. B.*, Dual phenazine gene clusters enable diversification during biosynthesis. Nat. Chem. Biol. 2019, 15, 331-339.
[5] Wang, G.#; Zhao Z.#; Ke, J.#; Engel, Y.#; Shi, Y.-M.#; Zhang, Z.; Bingol, K.; Robinson, D.; Wang, B.; Evans, R.; Miyamoto, Y.; Cheng, K.; Bowen, B.; Louie, K.; Kosina, S.; de Raad, M.; Silva, L.; Luhrs, A.; Lubbe, A.; Hoyt, W. D.; Francavilla, C.; Otani, H.; Deutsch, S.; Washton, M. N.; Rubin, E. M.; Mouncey, N. J.; Visel, A.; Cheng, J.-F.; Northen, T.; Bode, H. B.*; Yoshikuni, Y.* Chassis-independent recombinase-assisted genome engineering enables rapid activation of biosynthetic gene clusters in undomesticated bacteria. Nat. Microbiol. 2019, 4, 2498-2510
(*corresponding author; #equal contribution).