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Focused on stem cell directed differentiation and has established a series of therapeutically useful cell types from pluripotent stem cells including mesenchymal stromal cells (MSC) ; Notochord and nucleus pulposus cells (NPC); Retinal cells; Lung cells; Immune cells and expandable Cardiomyocytes, etc.
Prof. Qizhou LIAN, M.D., Ph. D., Dip. Pharm Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences，Shenzhen.
Professor Qizhou Lian was a Cardiology practitioner after he received doctoral degree of Medicine from Harbin Medical University in 1999. In 2001 he undertook postdoctoral training in the field of stem cell and regenerative medicine in the National University of Singapore, Genome Institute of Singapore and Utrecht University Medical Centre. In 2011 he took up Assistant Professor appointment at the Department of Medicine in the University of Hong Kong (HKU) and in 2019 Reader appointment in the University of Aberdeen, United Kingdom. In 2020 he returned to HKU and established the first cGMP manufacturing centre for cellular therapeutics. In 2023 he joined CAS-SIAT. In 2014, his team pioneered the Asia’s first hematopoietic stem cell gene therapy and successfully saved patients suffered from metachromatic leukodystrophy (MLD), a rare hereditary disease caused by accumulation of fats in brain called sulfatides. More recently, his lab aims to develop novel stem cell-based immunotherapy.
Contact：0755-21678021
Email: qz.lian@siat.ac.cn
Link: http://isynbio.siat.ac.cn/Lianlab/
Publications/Patents (selected)
[1]Jin L, Geng L, Ying L, Shu L, Ye K, Yang R, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan X, Liao B, Liu J, Duan F, Sweeney G, Woo CWH, Wang Y, Xia Z, Lian Q, Xu A. FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity. Circulation. 2022 Nov 15;146(20):1537-1557.
[2] Zhang Z, Guo L, Huang L, Zhang C, Luo R, Zeng L, Liang H, Li Q, Lu X, Wang X, Ma CY, Shao J, Luo W, Li L, Liu L, Li Z, Zhou X, Zhang X, Liu J, Yang J, Kwan KY, Liu W, Xu Y, Jiang H, Liu H, Du H, Wu Y, Yu G, Chen J, Wu J, Zhang J, Liao C, Chen HJ, Chen Z, Tse HF, Xia H, Lian Q. Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells. Clin Infect Dis. 2021 Dec 6;73(11):e4154-e4165.
[3] Geng L, Liao B, Jin L, Yu J, Zhao X, Zhao Y, Zhong L, Wang B, Li J, Liu J, Yang JK, Jia W, Lian Q, Xu A. β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130. Nat Metab. 2022 May;4(5):608-626.
[4] Lian Q, Zhang K, Zhang Z, Duan F, Guo L, Luo W, Mok BW, Thakur A, Ke X, Motallebnejad P, Nicolaescu V, Chen J, Ma CY, Zhou X, Han S, Han T, Zhang W, Tan AY, Zhang T, Wang X, Xu D, Xiang J, Xu A, Liao C, Huang FP, Chen YW, Na J, Randall G, Tse HF, Chen Z, Chen Y, Chen HJ. Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nat Commun. 2022 Apr 19;13(1):2028.
[5] Zhang Z, Yan B, Gao F, Li Q, Meng X, Chen P, Zhou L, Deng W, Li C, Xu W, Han S, Feng H, Li Y, Chen J, Yin Z, Liao C, Tse HF, Xu A, Lian Q. PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti's Crystalline Dystrophy. Mol Ther. 2020 Dec 2;28(12):2642-2661.