Synthetic immunology is an emerging discipline that is highly integrated with cutting-edge immunological theories and modern synthetic biology technology. This has greatly promoted the development of modern theories, technical approaches and product research of immunotherapy for major diseases. The Center for Synthetic Immunology is going to gather pioneers and outstanding young talents in synthetic immunology with the aim to cure tumors, autoimmune diseases, viral diseases, organ transplant and other diseases. Our approach is to provide new opportunities to reshape, renormalize, or rebuild the immune system of the body through immunotherapy. The center aims at applying new synthetic immunology theories and approaches to achieve the immunotherapy of major diseases and large-scale industrial production for treatment. At present, the center team is recruiting research groups in many disciplines including immunology, synthetic biology, structural biology, multi-omics and bioinformatics, biomacromolecule drugs, cell-based therapeutics and tissue or organ engineering.
Lab is credited with seminal discoveries regarding basic knowledge and clinical study of NK cells, particularly liver-resident NK cells, cytokine-producing NK cell subsets, and NK cell-based immunotherapy.
Tumor Immunology, Synthetic Immunology, Single cell genomics, T cell biology
The Shi Lab will focus on systematically decoding signaling network of immune cells by interdisciplinary approach, including novel mass spectrometry technique, to design new synthetic immunology therapeutics.
Infection-Immune-Tumor
Tumor immunology and Immunotherapy / Regulatory B cell in autoimmune diseases and tumor.
The main research directions are tumor synthetic biology, bladder cancer mechanism and tumor immune cell reprogramming.